Symbol
Name
ID

Lig4
ligase IV, DNA, ATP-dependent
MGI:1335098

Phenotype annotations related to nervous system

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Microcephaly	Anorexia	Spinal cord compression	Delayed speech and language development	Global developmental delay	Paresthesia
Disease(s) Associated with LIG4	Microcephaly	Anorexia	Spinal cord compression	Delayed speech and language development	Global developmental delay	Paresthesia
DNA ligase IV deficiency
multiple myeloma
pancreatic cancer

Mouse Phenotypes

nervous system phenotype

increased neuron apoptosis

increased forebrain apoptosis

increased spinal cord apoptosis

increased medulloblastoma incidence

abnormal brain development

decreased brain weight

decreased brain size

abnormal brainstem morphology

abnormal striatum morphology

abnormal diencephalon morphology

thin cerebral cortex

abnormal nervous system development

Availability

Mouse Genotype

Lig4^tm1Fwa/Lig4^tm1Fwa

Lig4^tm1Icrf/Lig4^tm1Icrf

Lig4^tm2.1Fwa/Lig4^tm2.1Fwa

Lig4^tm1Pmc/Lig4^tm1Pmc
Tg(Nes-cre)1Kln/0 (conditional)

Lig4^tm1Pmc/Lig4^tm1Pmc
Meox2^tm1(cre)Sor/Meox2⁺ (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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